Missouri City is a city in the U.S. state of Texas, within the Houston–The Woodlands–Sugar Land metropolitan area. The city is mostly in Fort Bend County, with a small portion in Harris County. As of the 2020 census, the city had a population of 74,259, an increase over the figure of 67,358 tabulated in 2010.

The area in which Missouri City is now located holds a significant part in the history of Texas that dates back to its early days as part of the United States. In August 1853, the Buffalo Bayou, Brazos and Colorado Railway (BBB&C) began operating its first 20 miles of rail line that stretched from Harrisburg (now Houston) to Stafford's Point (now Stafford). It was the first railroad to begin operating in Texas and the first standard gauge railroad west of the Mississippi River.

Missouri City is located in eastern Fort Bend County with a portion of the city extending north into Harris County. Missouri City is bordered by the city of Houston to the north and east, Stafford to the northwest, Sugar Land to the west, and Arcola to the southeast, as well as unincorporated communities such as Fifth Street to the north, Fresno to the east, and Sienna Plantation to the south. Downtown Houston is 17 miles to the northeast. Oyster Creek flows in a southerly direction through the municipality.